Screening Antibacterial Activity of Combination of Secang Extract (Caesalpinia sappan) and Clove oil (Syzigium aromaticum) Againts Propionibacterium acnes by Diffusion Method

Ni Luh Putu Vidya Paramita, Cokorda Istri Sri Arisanti, Ni Putu Linda Laksmiani

Abstrak


Propionobacterium acnes are common bacteria that cause an acne. It is populate in the  skin  and  induce  the  inflammatory  phase  of  acne.  The  methanolic  extract  of  secang (Caesalpinia sappan)  were proven that  have an antiacne potency and the clove oil (Syzigium aromaticum)  could  inhibit  the  growth  of  propionibacterium  acnes  by  disk  diffusion  method. The aim of this study is to investigated the potency of combination of both sample to inhibit Propionibacterium acnes  by  well diffusion  method. The results showed that the antibacterial assay  of  the  combination  of  methanolic  extract  secang  and  clove  oil  (1:1  v/v)  was  more effective than single samples. The combination could inhibit the growth of propionibacterium acnes with inhibition zone value is 19.3 mm. The inhibition zone value of methanolic extract of secang  (8  mg/mL)  and  clove  oil  (20  µl/mL)  respectively  is  17.6  mm  and  10.6  mm.  This combination  has  the  potential  to  be  developed  into  an  antiacne  product  so  it  requires  further research to find the right formula combination from both samples to enhance their activity.

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