Effect of Modification Diet On The Body Weight of sprangue dawley Rats

Abstract

Overweight can be due to increased consumption of high energy foods such as fats and  carbohydrates  with  low  physical  activity.  High-fat  diets  and  carbohydrates  with  less physical activity lead to an increase in the rate of fat accumulation. Fat will be deposited in the periphery and central, central fat deposits trigger the process of lipolysis to produce free fatty acids  that  cause  increased  production  of  glucose  in  the  liver,  reducing  the  absorption  of glucose in the muscle and inhibits the absorption of insulin into the liver. This study aims to determine  the  effect  of  modified  diet  compared  to  standard  feed  (Rat  Bio)  on  the  weight  of Sprangue dawley rat. The research was conducted during April - June 2018 at the Biomedical Laboratory of Dentistry  Faculty University of Jember. This research  method is experimental with pre-post control group design. The subject of research is 12 male Sprangue dawley rats, applying  from  LPPT  4  Universias  Gadjah  Mada  Yogyakarta.  The  rats  were  divided  into  2 groups: control and treatment. The control group was fed standard Rat Bio while the treatment group  was  modified diet for  6  weeks.  The  result  of  paired  T-Test  in  the  treatment  group (modified  diet) showed  that  there  was  significant  weight  difference  between  pretest  and posttest (p = 0,01), while in control group (Rat Bio) showed no significant weight difference between pretest and postest (p = 0.05). T-test result of body weight difference between the two groups showed significant difference (p = 0,01) between control group (Rat Bio) and treatment group (modified diet), where the difference of weight gain in treatment group was higher than control group. From this study it can be concluded that feeding of modified diet has an effect on the increase in body weight of Sprangue dawley rat.