The Potential of beta-glucan as feed additives in broiler chickens: A review
DOI:
https://doi.org/10.25047/jipt.v6i1.3297Keywords:
antibiotic alternative, beta-glucans, growth promoter, immunomodulation, poultryAbstract
Poultry as an industry was continuously growing worldwide and demands for poultry meats were markedly increasing. However, the limited use of antibiotics as treatments and as growth promoters became a serious problem due to the emergence of antibiotic resistance. Therefore, exploring other alternatives such as using feed additives like beta-glucans were widely studied and used to meet the demands of the consumers. This review focused on the different functions and effects of beta-glucans in poultry. Beta-glucans were known to have immunomodulation effects by upregulating the cytokines and other immune cells to overcome a disease. Aside from its immunomodulation effects, it can also increase the intestinal villi and crypts. Furthermore, an increase in growth performance was also observed. This evidence is promising but further research is required to properly establish the various functions of beta-glucans in poultry.
Downloads
References
Abd El Tawab, A., Elnaggar, O., & Elsissi, A. (2019). The impact of β glucan on the Immune Response of Broiler Chickens Vaccinated with NDV and AI H9V Vaccines. Benha Veterinary Medical Journal, 36(2), 100–108. https://doi.org/10.21608/bvmj.2019.13775.1021
Ahiwe, E. U., Omede, A. A., Abdallh, M. E., Chang’a, E. P., Al-Qahtani, M., Gausi, H., Graham, H., & Iji, P. A. (2019). Response of Broiler Chickens to Dietary Supplementation of Enzymatically Hydrolyzed Glucan or Mannan Yeast Products. Journal of Applied Poultry Research, 28(4), 892–901. https://doi.org/10.3382/japr/pfz047
Anwar, M. I., Muhammad, F., Awais, M. M., & Akhtar, M. (2017). A review of ß-glucans as a growth promoter and antibiotic alternative against enteric pathogens in poultry. World’s Poultry Science Journal, 73(3), 651–661. https://doi.org/10.1017/S0043933917000241
Bae, I. Y., Lee, S., Kim, S. M., & Lee, H. G. (2009). Effect of partially hydrolyzed oat β-glucan on the weight gain and lipid profile of mice. Food Hydrocolloids, 23(7), 2016–2021. https://doi.org/10.1016/j.foodhyd.2009.03.016
Bashir, K. M. I., & Choi, J. S. (2017). Clinical and physiological perspectives of β-glucans: The past, present, and future. International Journal of Molecular Sciences, 18(9). https://doi.org/10.3390/ijms18091906
Chamidah, A., Hardoko, & Prihanto, A. A. (2017). Antibacterial activities of β-glucan (laminaran) against gram-negative and gram-positive bacteria. AIP Conference Proceedings, 1844(May 2017). https://doi.org/10.1063/1.4983422
Cho, J. H., Zhang, Z. F., & Kim, I. H. (2013). Effects of single or combined dietary supplementation of β-glucan and kefir on growth performance, blood characteristics and meat quality in broilers. British Poultry Science, 54(2), 216–221. https://doi.org/10.1080/00071668.2013.777691
de Oliveira, C. A. F., Vetvicka, V., & Zanuzzo, F. S. (2019). β-Glucan successfully stimulated the immune system in different jawed vertebrate species. Comparative Immunology, Microbiology and Infectious Diseases, 62(November 2018), 1–6. https://doi.org/10.1016/j.cimid.2018.11.006
Ding, B., Zheng, J., Wang, X., Zhang, L., Sun, D., Xing, Q., Pirone, A., & Fronte, B. (2019). Effects of dietary yeast beta-1,3-1,6-glucan on growth performance, intestinal morphology and chosen immunity parameters changes in Haidong chicks. Asian-Australasian Journal of Animal Sciences, 32(10), 1558–1564. https://doi.org/10.5713/ajas.18.0962
Du, B., Meenu, M., Liu, H., & Xu, B. (2019). A concise review on the molecular structure and function relationship of β-glucan. International Journal of Molecular Sciences, 20(16). https://doi.org/10.3390/ijms20164032
El Khoury, D., Cuda, C., Luhovyy, B. L., & Anderson, G. H. (2012). Beta glucan: Health benefits in obesity and metabolic syndrome. Journal of Nutrition and Metabolism, 2012. https://doi.org/10.1155/2012/851362
ElSawy, A., ElMaddawy, Z., & BoGhazel, H. (2015). The Growth Promoting Effect of Beta-glucan in Comparison with Sodium Butyrate in Broiler Chicks. Alexandria Journal of Veterinary Sciences, 44(1), 23. https://doi.org/10.5455/ajvs.163992
Fadl, S. E., El-Gammal, G. A., Sakr, O. A., Salah, A. A. B. S., Atia, A. A., Prince, A. M., & Hegazy, A. M. (2020). Impact of dietary Mannan-oligosaccharide and β-Glucan supplementation on growth, histopathology, E-coli colonization and hepatic transcripts of TNF-α and NF-Ï°B of broiler challenged with E. coli O78. BMC Veterinary Research, 16(1), 1–14. https://doi.org/10.1186/s12917-020-02423-2
Ferket, P. R., Parks, C. W., & Grimes, J. L. (2002). Benefits of Dietary Antibiotic and Mannanoligosaccharide Supplementation for Poultry. Multi-State Poultry Meeting, 1–22. http://www.feedinfo.com/files/multi2002-ferket.pdf
Geller, A., Shrestha, R., & Yan, J. (2019). Yeast-derived β-glucan in cancer: Novel uses of a traditional therapeutic. International Journal of Molecular Sciences, 20(15), 1–20. https://doi.org/10.3390/ijms20153618
Gómez, S., Angeles, M. L., Mojica, M. C., & Jalukar, S. (2012). Combination of an enzymatically hydrolyzed yeast and yeast culture with a direct-fed microbial in the feeds of broiler chickens. Asian-Australasian Journal of Animal Sciences, 25(5), 665–673. https://doi.org/10.5713/ajas.2011.11316
Hadiuzzaman, M., Moniruzzaman, M., Shahjahan, M., Bai, S. C., Min, T., & Hossain, Z. (2022). β-Glucan: Mode of Action and Its Uses in Fish Immunomodulation. Frontiers in Marine Science, 9(July), 1–15. https://doi.org/10.3389/fmars.2022.905986
Imanpour-jodey, S., Moghaddaszadeh-ahrabi, S., & Rezapour, A. (2013). The effects of saccharomyces cervisiae beta-glucan on blood lipids in broiler chickens The effects of saccharomyces cervisiae beta-glucan on blood lipids in broiler chickens. 4(September 2014), 134–137.
Jacob, J. P., & Pescatore, A. J. (2014). Barley β-glucan in poultry diets. Annals of Translational Medicine, 2(2). https://doi.org/10.3978/j.issn.2305-5839.2014.01.02
Jacob, J., & Pescatore, A. (2017). Glucans and the poultry immune system. American Journal of Immunology, 13(1), 45–49. https://doi.org/10.3844/ajisp.2017.45.49
Jahanian, R., & Ashnagar, M. (2015). Effect of dietary supplementation of mannan-oligosaccharides on performance, blood metabolites, ileal nutrient digestibility, and gut microflora in Escherichia coli-challenged laying hens. Poultry Science, 94(9), 2165–2172. https://doi.org/10.3382/ps/pev180
Karunaratne, N. D., Newkirk, R. W., Ames, N. P., van Kessel, A. G., Bedford, M. R., & Classen, H. L. (2021). Effects of exogenous β-glucanase on ileal digesta soluble β-glucan molecular weight, digestive tract characteristics, and performance of coccidiosis vaccinated broiler chickens fed hulless barley-based diets with and without medication. PLoS ONE, 16(5 May), 1–30. https://doi.org/10.1371/journal.pone.0236231
Kaur, R., Sharma, M., Ji, D., Xu, M., & Agyei, D. (2020). Structural Features, Modification, and Functionalities of Beta-Glucan. Fibers, 1–29.
Landers, T. F., Cohen, B., Wittum, T. E., & Larson, E. L. (2012). A review of antibiotic use in food animals: Perspective, policy, and potential. Public Health Reports, 127(1), 4–22. https://doi.org/10.1177/003335491212700103
Lindmeier, C. (2017). Stop using antibiotics in healthy animals to prevent the spread of antibiotic resistance. World Health Organization. https://www.who.int/news/item/07-11-2017-stop-using-antibiotics-in-healthy-animals-to-prevent-the-spread-of-antibiotic-resistance
M’sadeq, S. A., Wu, S. B., Choct, M., Forder, R., & Swick, R. A. (2015). Use of yeast cell wall extract as a tool to reduce the impact of necrotic enteritis in broilers. Poultry Science, 94(5), 898–905. https://doi.org/10.3382/ps/pev035
Moon, S. H., Lee, I., Feng, X., Lee, H. Y., Kim, J., & Ahn, D. U. (2016). Effect of dietary beta-glucan on the performance of broilers and the quality of broiler breast meat. Asian-Australasian Journal of Animal Sciences, 29(3), 384–389. https://doi.org/10.5713/ajas.15.0141
Omara, I. I., Pender, C. M., White, M. B., & Dalloul, R. A. (2021). The modulating effect of dietary beta-glucan supplementation on expression of immune response genes of broilers during a coccidiosis challenge. Animals, 11(1), 1–12. https://doi.org/10.3390/ani11010159
Ott, C. P. (2015). Impact of Dietary Beta-glucan Supplementation on Performance and Immune Response of Broiler Chickens During Challenge. https://vtechworks.lib.vt.edu/handle/10919/75170
Ott, C. P., Omara, I. I., Persia, M. E., & Dalloul, R. A. (2018). The impact of β-glucans on performance and response of broiler chickens during a coccidiosis challenge. Poultry Science, 97(8), 2713–2721. https://doi.org/10.3382/ps/pey148
Pascual, A., Pauletto, M., Giantin, M., Radaelli, G., Ballarin, C., Birolo, M., Zomeño, C., Dacasto, M., Bortoletti, M., Vascellari, M., Xiccato, G., & Trocino, A. (2020). Effect of dietary supplementation with yeast cell wall extracts on performance and gut response in broiler chickens. Journal of Animal Science and Biotechnology, 11(1), 1–11. https://doi.org/10.1186/s40104-020-00448-z
Petit, J., Bailey, E. C., Wheeler, R. T., Oliveira, C. A. F. D., Forlenza, M., & Wiegertjes, G. F. (2019). Studies into β-glucan recognition in fish suggests a key role for the C-Type lectin pathway. Frontiers in Immunology, 10(FEB). https://doi.org/10.3389/fimmu.2019.00280
Pirgozliev, V., Rose, S. P., & Ivanova, S. (2019). Feed additives in poultry nutrition. Bulgarian Journal of Agricultural Science, 25, 8–11.
Ruiz-Herrera, J., & Ortiz-Castellanos, L. (2019). Cell wall glucans of fungi. A review. Cell Surface, 5(November 2018), 100022. https://doi.org/10.1016/j.tcsw.2019.100022
Sadeghi, A. A., Mohammadi, A., Shawrang, P., & Aminafshar, M. (2013). Immune responses to dietary inclusion of prebiotic-based mannan-oligosaccharide and β-glucan in broiler chicks challenged with Salmonella enteritidis. Turkish Journal of Veterinary and Animal Sciences, 37(2), 206–213. https://doi.org/10.3906/vet-1203-9
Samuelsen, A. B. C., Schrezenmeir, J., & Knutsen, S. H. (2014). Effects of orally administered yeast-derived beta-glucans: A review. In Molecular Nutrition and Food Research (Vol. 58, Issue 1, pp. 183–193). https://doi.org/10.1002/mnfr.201300338
Schwartz, B., & Vetvicka, V. (2021). Review: β‐glucans as effective antibiotic alternatives in poultry. Molecules, 26(12), 1–12. https://doi.org/10.3390/molecules26123560
Shao, Y., Guo, Y., & Wang, Z. (2013). β-1,3/1,6-Glucan alleviated intestinal mucosal barrier impairment of broiler chickens challenged with Salmonella enterica serovar Typhimurium. Poultry Science, 92(7), 1764–1773. https://doi.org/10.3382/ps.2013-03029
Stier, H., Ebbeskotte, V., & Gruenwald, J. (2014). Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan. Nutrition Journal, 13(1), 1–9. https://doi.org/10.1186/1475-2891-13-38
Tian, X., Shao, Y., Wang, Z., & Guo, Y. (2016). Effects of dietary yeast β-glucans supplementation on growth performance, gut morphology, intestinal Clostridium perfringens population and immune response of broiler chickens challenged with necrotic enteritis. Animal Feed Science and Technology, 215(2), 144–155. https://doi.org/10.1016/j.anifeedsci.2016.03.009
Vangroenweghe, F., Poulsen, K., & Thas, O. (2021). Supplementation of a β-mannanase enzyme reduces post-weaning diarrhea and antibiotic use in piglets on an alternative diet with additional soybean meal. Porcine Health Management, 7(1), 1–12. https://doi.org/10.1186/s40813-021-00191-5
Vetvicka, V., & Oliveira, C. (2014). β(1-3)(1-6)-D-Glucan with Strong Effects on Immune Status in Chicken: Potential Importance for Efficiency of Commercial Farming. Journal of Nutrition and Health Sciences, November, 1–7. https://doi.org/10.15744/2393-9060.1.309
Vlassopoulou, M., Yannakoulia, M., Pletsa, V., Zervakis, G. I., & Kyriacou, A. (2021). Effects of fungal beta-glucans on health-a systematic review of randomized controlled trials. Food and Function, 12(8), 3366–3380. https://doi.org/10.1039/d1fo00122a
Wang, M., Yang, R., Zhang, L., Meng, X., Fei, C., Zhang, K., Wang, X., Zheng, W., Xiao, S., Zhang, S., Xue, F., & Hu, Y. (2014). Sulfated glucan can improve the immune efficacy of Newcastle disease vaccine in chicken. International Journal of Biological Macromolecules, 70, 193–198. https://doi.org/10.1016/j.ijbiomac.2014.05.048
Werf, M. van der. (2018). Benefits of Application of Yeast β -Glucans in Poultry. Ohly, 1–3.
Xin, Y., Ji, H., Cho, E., Roh, K. B., You, J., Park, D., & Jung, E. (2022). Immune-enhancing effect of water-soluble beta-glucan derived from enzymatic hydrolysis of yeast glucan. Biochemistry and Biophysics Reports, 30(January), 101256. https://doi.org/10.1016/j.bbrep.2022.101256
Yang, F., Zhang, F., Li, H., Wu, H., Zhao, H., Cheng, X., Ba, Y., Huang, H., Chen, S., & Zhu, J. (2021). Contribution of environmental factors on the distribution of antibiotic resistance genes in agricultural soil. European Journal of Soil Biology, 102(December 2020), 103269. https://doi.org/10.1016/j.ejsobi.2020.103269
Zhang, S., Ou, J., Luo, Z., & Kim, I. H. (2020). Effect of dietary β-1,3-glucan supplementation and heat stress on growth performance, nutrient digestibility, meat quality, organ weight, ileum microbiota, and immunity in broilers. Poultry Science, 99(10), 4969–4977. https://doi.org/10.1016/j.psj.2020.06.036
Zhang, Z. F., Zhou, T. X., Ao, X., & Kim, I. H. (2012). Effects of Β-glucan and Bacillus subtilis on growth performance, blood profiles, relative organ weight and meat quality in broilers fed maize-soybean meal based diets. Livestock Science, 150(1–3), 419–424. https://doi.org/10.1016/j.livsci.2012.10.003
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Jurnal Ilmu Peternakan Terapan

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.